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FANTOM5项目放出人类基因组基因表达精细图

放大字体  缩小字体 发布日期:2015-07-17  浏览次数:433
核心提示:2014年4月3日讯 /生物谷BIOON/ --近日由日本理化研究所(RIKEN)牵头推动的国际合作项目FANTOM(Functional Annotation of the M
 

2014年4月3日讯 /生物谷BIOON/ --近日由日本理化研究所(RIKEN)牵头推动的国际合作项目FANTOM(Functional Annotation of the Mammalian Genome)放出了第一版人类基因组基因活性精细图。该精细图是RIKEN和FANTOM项目组经过多年对人类基因组基因表带调控的系统性研究所得出的突破性成果。相关的18篇文章已于近日发表在Nature等11本杂志上。

FANTOM项目是由RIKEN于2000年发起的,旨在建立全方位的人类基因组基因表达数据库。20个国家和地区的超过250名细胞生物学和生物信息学专家,114个研究所参加到了这个项目中。该项目中所用到的主要技术为RIKEN所发展出的Cap Analysis of Gene expression(CAGE)技术,该技术的优势在于对于基因表达水平的测定具有更高的敏感性。

附两篇相关Nature文章:
Forrest A.R.R. et al. A promoter level mammalian expression atlas. Nature (2014)doi:10.1038/nature13182.Andersson, R. et al. An atlas of active enhancers across human cell types and tissues. Nature (2014) doi:10.1038/nature12787(生物谷Bioon.com)

详细英文报道:

FANTOM, a large international consortium led by RIKEN releases today the first comprehensive map of gene activity across the human body, and provides the first holistic view of the complex networks that regulate gene expression across the wide variety of cell types that make up a human being. These findings will help in the identification of genes involved in disease and the development of personalized and regenerative medicine.


After many years of concerted effort to systematically analyze the expression of genes in all human cells and tissues, RIKEN and the FANTOM consortium publish the findings today in two landmark Nature reports, and 16 related articles in ten other scholarly journals.

The papers published in Nature describe maps of promoters and enhancers - short regions of DNA that influence the activity of genes - encoded in the human genome, and their activity across the vast wealth of human cell types and tissues of the human body. Together with the other studies published by FANTOM5, this data provides the first complete view of the networks regulating transcription across all cell types.

The FANTOM project (for Functional Annotation of the Mammalian genome) is a RIKEN initiative launched in 2000 to build a complete library of human genes using the capabilities offered by new, state-of-the-art cDNA technologies. Over 250 experts in primary cell biology and bioinformatics from 114 institutions based in more than 20 countries and regions worked as part of FANTOM 5, the 5th edition of the project, to produce the 18 studies published today.

Using a highly sensitive technique called Cap Analysis of Gene expression (CAGE), developed at RIKEN, the researchers monitored the activity of promoters and enhancers across over 180 human primary cells. They identified 180,000 promoters and 44000 enhancers on the genome and find that the activity of the large majority of these transcriptional regulation regions is highly specific to cell type.

 
 
 
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